Ou Dipeng, Yang Hao, Hua Dong, Xiao Shuai, Yang Lianyue
Department of Geratic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Oncotarget. 2015 Jul 10;6(19):17379-90. doi: 10.18632/oncotarget.3954.
Transmembrane protein 100 (TMEM100) was activated by ALK1/TGF-β signaling. We found that TMEM100 was decreased in hepatocellular carcinoma (HCC) tissues and in highly metastatic cell lines. Overexpressed of TMEM100 inhibited invasion, migration and proliferation. Low levels of TMEM100 were associated with cirrhosis, tumor size, Tumor nodule number, TNM stage, BCLC stage, Edmondson-Steiner Stage and vein invasion. Furthermore, TMEM100 was an independent risk factor for overall survival (P = 0.03) and disease-free survival (P = 0.019). The current findings suggest that TMEM100 functions as a tumor suppressor in HCC metastasis and proliferation.
跨膜蛋白100（TMEM100）被ALK1/TGF-β信号通路激活。我们发现，TMEM100在肝细胞癌（HCC）组织和高转移细胞系中表达降低。TMEM100过表达抑制侵袭、迁移和增殖。低水平的TMEM100与肝硬化、肿瘤大小、肿瘤结节数量、TNM分期、BCLC分期、Edmondson-Steiner分期及静脉侵犯相关。此外，TMEM100是总生存（P = 0.03）和无病生存（P = 0.019）的独立危险因素。目前的研究结果表明，TMEM100在HCC转移和增殖中发挥肿瘤抑制作用。
