Shrimankar J, Soni S D, McMurray J
Prestwich Hospital, Manchester.
Br J Psychiatry. 1989 Mar;154:372-7. doi: 10.1192/bjp.154.3.372.
To determine the usefulness of the DST in differentiating depression from dementia, the test was administered to three diagnostic groups of psychogeriatric patients: depression; dementia; and dementia with depression. Clinical assessments were supplemented by ratings on the HRSD and SCAG, as well as by EEG and CT. All three groups showed a high incidence of abnormal DST results unrelated to presence or severity of affective symptoms, but showing a better association with SCAG and its 'organic' subsets. The mechanism(s) underlying these abnormal results may reflect organic brain disease. The usefulness of the DST in differentiating depression from dementia in the elderly was not confirmed.
为了确定地塞米松抑制试验（DST）在区分抑郁症与痴呆症方面的效用，该测试应用于三类老年精神科诊断患者：抑郁症患者；痴呆症患者；以及伴有抑郁症的痴呆症患者。通过汉密尔顿抑郁量表（HRSD）和简易精神状况检查表（SCAG）评分、脑电图（EEG）及计算机断层扫描（CT）对临床评估进行补充。所有三组患者的DST结果异常发生率都很高，这与情感症状的存在或严重程度无关，但与SCAG及其“器质性”亚组的关联性更好。这些异常结果背后的机制可能反映了器质性脑疾病。DST在区分老年人抑郁症与痴呆症方面的效用未得到证实。
