Liddington M, Richardson A J, Higgins R M, Endre Z H, Venning V A, Murie J A, Morris P J
Nuffield Department of Surgery Transplant Unit, University of Oxford, Churchill Hospital, Headington, UK.
Br J Surg. 1989 Oct;76(10):1002-5. doi: 10.1002/bjs.1800761005.
Skin cancer was found in 31 of 598 patients transplanted in Oxford. No cases occurred during the first 3 years after transplantation but the prevalence rose after 12 years to 18.2 per cent. The main risk factors predisposing to skin cancer were the time after transplantation and male sex. Comparison with data from other centres suggests that exposure to ultraviolet light is a major aetiological factor in the speed of development of skin cancer. As the incidence of new cases rose progressively with time in our patients, it would seem that skin cancer is likely to become a major clinical problem as more patients enjoy prolonged survival after renal transplantation. Preventative and screening measures should be taken by transplant units both in the UK and in other countries with similar temperate climates.
在牛津接受移植的598名患者中，有31人被发现患有皮肤癌。移植后的前3年未出现病例，但12年后患病率升至18.2%。易患皮肤癌的主要危险因素是移植后的时间和男性性别。与其他中心的数据比较表明，紫外线照射是皮肤癌发展速度的一个主要病因因素。由于我们患者中新发病例的发生率随时间逐渐上升，随着更多患者在肾移植后存活时间延长，皮肤癌似乎可能成为一个主要的临床问题。英国和其他气候类似的温带国家的移植单位应采取预防和筛查措施。
