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头颈部鳞状细胞癌的全身治疗

Systemic therapy for squamous cell carcinoma of the head and neck.

作者信息

Pancari Philip, Mehra Ranee

机构信息

Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

出版信息

Surg Oncol Clin N Am. 2015 Jul;24(3):437-54. doi: 10.1016/j.soc.2015.03.004.

DOI:10.1016/j.soc.2015.03.004
PMID:25979393
Abstract

The use of systemic therapy as part of curative treatment and palliation is an evolving paradigm for squamous cell cancer of the head and neck (SCCHN), which historically has been treated with local modalities. At present, the treatment armamentarium includes traditional cytotoxic therapy, targeted biological agents, and emerging immunotherapeutics. This article discusses the use of all of these systemic approaches for the curative and palliative treatment of SCCHN.

摘要

全身治疗作为根治性治疗和姑息治疗的一部分,是头颈部鳞状细胞癌(SCCHN)不断发展的治疗模式,而头颈部鳞状细胞癌在历史上一直采用局部治疗方法。目前,治疗手段包括传统的细胞毒性疗法、靶向生物制剂和新兴的免疫疗法。本文讨论了所有这些全身治疗方法在头颈部鳞状细胞癌根治性和姑息性治疗中的应用。

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Front Oncol. 2018 Nov 28;8:563. doi: 10.3389/fonc.2018.00563. eCollection 2018.
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Proton Radiotherapy for Recurrent or Metastatic Head and Neck Cancers with Palliative Quad Shot.质子放疗用于复发性或转移性头颈部癌的姑息四联照射
Int J Part Ther. 2018 Spring;4(4):10-19. doi: 10.14338/IJPT-18-00003.1.
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Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro.
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J Vis Exp. 2018 Jul 17(137):56317. doi: 10.3791/56317.
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Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors.LIM蛋白AJUBA的突变介导头颈部鳞状细胞癌对细胞周期抑制剂治疗的敏感性。
Cancer Lett. 2017 Apr 28;392:71-82. doi: 10.1016/j.canlet.2017.01.024. Epub 2017 Jan 23.
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Downregulation of Microrna-126 Contributes to Tumorigenesis of Squamous Tongue Cell Carcinoma via Targeting KRAS.微小RNA-126的下调通过靶向KRAS促进舌鳞状细胞癌的肿瘤发生。
Med Sci Monit. 2016 Feb 17;22:522-9. doi: 10.12659/msm.895306.
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Knockdown of CLIC4 enhances ATP-induced HN4 cell apoptosis through mitochondrial and endoplasmic reticulum pathways.CLIC4基因敲低通过线粒体和内质网途径增强ATP诱导的HN4细胞凋亡。
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