Berridge D C, Hopkinson B R, Makin G S
Department of Vascular Surgery, University Hospital, Nottingham, UK.
Br J Surg. 1989 Oct;76(10):1021-3. doi: 10.1002/bjs.1800761011.
Simultaneous readings of transcutaneous partial pressure of oxygen (Ptc,O2) were obtained from the left anterior chest wall, from 10 cm distal to the medial aspect of the knee joint, and from the first dorsal webspace in 16 patients with acute peripheral arterial ischaemia of the leg. Oxygen was administered at concentrations of 24, 40, 60 and 100 per cent. Mean (s.d.) initial chest Ptc,O2 (53(17)mmHg) was significantly higher than that of the medial lower limb site (37(17)mmHg). After inhalation of 24 per cent oxygen, a statistically significant (P less than 0.025) increase in chest Ptc,O2 was achieved (63(20)mmHg), but the increase in Ptc,O2 (43(19)mmHg) at the medial lower limb site was not statistically significant. Inhalation of 40 per cent oxygen resulted in significant increases at both sites (chest: 83(23)mmHg, P less than 0.01; limb: 53(26)mmHg, P less than 0.05). Ptc,O2 in the limb at this concentration of inhaled oxygen was equal to the initial chest level. Increasing the oxygen concentration to 60 per cent and then to 100 per cent produced further significant (P less than 0.001) increases in Ptc,O2 at both sites. The use of continuous oxygen inhalation during acute ischaemia may improve tissue nutrition before, during and after definitive treatment.
对16例急性下肢周围动脉缺血患者，同时从左前胸壁、膝关节内侧10厘米远侧以及第一背侧指蹼间隙读取经皮氧分压（Ptc,O2）。分别给予浓度为24%、40%、60%和100%的氧气。平均（标准差）初始胸部Ptc,O2为（53(17)mmHg），显著高于下肢内侧部位（37(17)mmHg）。吸入24%氧气后，胸部Ptc,O2有统计学意义（P<0.025）的升高（63(20)mmHg），但下肢内侧部位Ptc,O2的升高（43(19)mmHg）无统计学意义。吸入40%氧气后，两个部位的Ptc,O2均显著升高（胸部：83(23)mmHg，P<0.01；肢体：53(26)mmHg，P<0.05）。在此吸入氧浓度下，肢体的Ptc,O2与初始胸部水平相当。将氧浓度增至60%，然后再增至100%，两个部位的Ptc,O2进一步显著升高（P<0.001）。在急性缺血期间持续吸氧，可能会在确定性治疗之前、期间和之后改善组织营养。
