微小RNA概述
An overview of microRNAs.
作者信息
Hammond Scott M
机构信息
Department of Cell Biology and Physiology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
出版信息
Adv Drug Deliv Rev. 2015 Jun 29;87:3-14. doi: 10.1016/j.addr.2015.05.001. Epub 2015 May 12.
Abstract
The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in molecular biology. There are now over 2000 miRNAs that have been discovered in humans and it is believed that they collectively regulate one third of the genes in the genome. miRNAs have been linked to many human diseases and are being pursued as clinical diagnostics and as therapeutic targets. This review presents an overview of the miRNA pathway, including biogenesis routes, biological roles, and clinical approaches.
摘要
20多年前首个微小RNA（miRNA）的发现开创了分子生物学的新纪元。目前在人类中已发现2000多种miRNA，人们认为它们共同调控着基因组中三分之一的基因。miRNA与许多人类疾病有关，正被作为临床诊断标志物和治疗靶点进行研究。本文综述了miRNA通路，包括其生物合成途径、生物学作用及临床应用。
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