对环丙沙星中度敏感的伤寒沙门菌血清型 Typhi 和甲型副伤寒沙门菌分离株中不存在多重耐药性。
Absence of multidrug resistance in Salmonella enterica serotypes Typhi and Paratyphi A isolates with intermediate susceptibility to ciprofloxacin.
作者信息
Misra Richa, Prasad K N, Amrin N, Kapoor P, Singh Swati, Ghar Malay
机构信息
Department of Microbiology, Section Bacteriology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow-226014, Uttar Pradesh, India
Department of Microbiology, Section Bacteriology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow-226014, Uttar Pradesh, India.
出版信息
Trans R Soc Trop Med Hyg. 2015 Aug;109(8):538-40. doi: 10.1093/trstmh/trv036. Epub 2015 May 15.
BACKGROUND
We describe the antimicrobial susceptibility pattern of 64 blood stream isolates of Salmonella enterica serotypes Typhi and Paratyphi A studied from January 2013 to December 2014 at a tertiary care centre in North India.
METHODS
Isolates were identified by standard biochemical reactions and confirmed by slide agglutination using specific antisera. Antimicrobial susceptibility testing was performed by Kirby-Bauer disc diffusion method and by E-test.
RESULTS
In this study, 92% (46/50) of Salmonella Typhi and all Paratyphi A (n=14) isolates were susceptible to ampicillin, chloramphenicol and cotrimoxazole. Eighty percent of Typhi (40/50) and 64% (9/14) of Paratyphi A were intermediately susceptible to ciprofloxacin. Nineteen percent (12/64) of isolates were resistant to ciprofloxacin. No resistance to ceftriaxone and azithromycin was detected.
CONCLUSIONS
Our study adds to the current knowledge of world-wide reports of multidrug resistance in S. Typhi.
背景
我们描述了2013年1月至2014年12月在印度北部一家三级护理中心研究的64株伤寒沙门氏菌血清型伤寒和甲型副伤寒血流分离株的抗菌药敏模式。
方法
通过标准生化反应鉴定分离株，并使用特异性抗血清通过玻片凝集进行确认。采用 Kirby-Bauer 纸片扩散法和 E-test 进行抗菌药敏试验。
结果
在本研究中，92%（46/50）的伤寒沙门氏菌和所有甲型副伤寒（n = 14）分离株对氨苄西林、氯霉素和复方新诺明敏感。80%的伤寒沙门氏菌（40/50）和64%的甲型副伤寒（9/14）对环丙沙星中度敏感。19%（12/64）的分离株对环丙沙星耐药。未检测到对头孢曲松和阿奇霉素的耐药性。
结论
我们的研究增加了目前全球关于伤寒沙门氏菌多重耐药性报告的知识。
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