Martin-Rodriguez Elena, Guillen-Grima Francisco, Martí Amelia, Brugos-Larumbe Antonio
Departament of Health Science, Public University of Navarra, Pamplona, Spain; Servicio Navarro de Salud, Spain.
Departament of Health Science, Public University of Navarra, Pamplona, Spain; Departament of Preventive Medicine, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain; IdiSNA (Navarra Institute for Health Research), Spain.
Obes Res Clin Pract. 2015 Sep-Oct;9(5):435-47. doi: 10.1016/j.orcp.2015.04.003. Epub 2015 May 13.
Overweight and obesity are major causes of comorbidities which can lead to further morbidity and mortality. The main objective of the present study was to estimate the comorbidity associated with obesity in 40,010 patients attending Primary Health Care Centres in Navarra.
It is a descriptive cross-sectional study. The association of overweight and obesity in different diseases was studied. Odds ratios (OR) adjusted for age and sex were calculated by unconditional logistic regression, using as reference patients with body mass index (BMI) lower than 25 kg/m(2).
Increasing BMI is associated with glucose intolerance (OR: 1.07; 95% CI: 1.06-1.08), dyslipidemia (OR: 1.04; 95% CI: 1.03-1.04), hypertension (OR: 1.12; 95% CI: 1.12-1.13), type 2 diabetes (OR: 1.11; 95% CI: 1.10-1.11), kidney failure (OR: 1.04; 95% CI: 1.03-1.05), and osteoarthritis (OR: 1.06; 95% CI: 1.05-1.06). Moreover, all the degrees of obesity are associated with asthma (OR type I obesity: 1.33; OR type II obesity: 1.69; OR type III obesity: 1.75), heart failure (OR type I obesity: 1.68; OR type II obesity: 2.78; OR type III obesity: 4.35), and severe mental disorders (OR type I obesity: 2.02; OR type II obesity: 2.33; OR type III obesity: 2.50). Type II and morbid obesity are associated with chronic obstructive pulmonary disease and depression.
Our study showed a positive association of the overweight and obesity with glucose intolerance, dyslipidemia, type 2 diabetes, hypertension, osteoarthritis, and kidney failure. An interesting point is the association of higher levels of BMI with depression.
超重和肥胖是合并症的主要原因，可导致进一步的发病和死亡。本研究的主要目的是评估纳瓦拉初级卫生保健中心的40,010名患者中与肥胖相关的合并症。
这是一项描述性横断面研究。研究了超重和肥胖与不同疾病之间的关联。通过无条件逻辑回归计算年龄和性别调整后的比值比（OR），以体重指数（BMI）低于25 kg/m²的患者作为参照。
BMI升高与葡萄糖耐量异常（OR：1.07；95%可信区间：1.06 - 1.08）、血脂异常（OR：1.04；95%可信区间：1.03 - 1.04）、高血压（OR：1.12；95%可信区间：1.12 - 1.13）、2型糖尿病（OR：1.11；95%可信区间：1.10 - 1.11）、肾衰竭（OR：1.04；95%可信区间：1.03 - 1.05）和骨关节炎（OR：1.06；95%可信区间：1.05 - 1.06）相关。此外，所有肥胖程度均与哮喘（I型肥胖OR：1.33；II型肥胖OR：1.69；III型肥胖OR：1.75）、心力衰竭（I型肥胖OR：1.68；II型肥胖OR：2.78；III型肥胖OR：4.35）和严重精神障碍（I型肥胖OR：2.02；II型肥胖OR：2.33；III型肥胖OR：2.50）相关。II型肥胖和病态肥胖与慢性阻塞性肺疾病和抑郁症相关。
我们的研究表明超重和肥胖与葡萄糖耐量异常、血脂异常、2型糖尿病、高血压、骨关节炎和肾衰竭呈正相关。一个有趣的发现是较高的BMI水平与抑郁症相关。
