Department of Growth and ReproductionGR-5064, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
Department of Growth and ReproductionGR-5064, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
Eur J Endocrinol. 2015 Aug;173(2):227-35. doi: 10.1530/EJE-15-0239. Epub 2015 May 15.
Early pubertal timing is consistently associated with increased BMI percentile-for-age in pubertal girls, while data in boys are more ambiguous. However, higher BMI percentile-for-age may be a result of the earlier puberty per se rather than vice versa. The aim was to evaluate markers of adiposity in relation to pubertal timing and reproductive hormone levels in healthy pubertal boys and girls.
Population-based cross-sectional study (The Copenhagen Puberty Study). Eight-hundred and two healthy Caucasian children and adolescents (486 girls) aged 8.5-16.5 years participated. BMI and bioelectric impedance analyses (BIA) were used to estimate adiposity. Clinical pubertal markers (Tanner stages and testicular volume) were evaluated. LH, FSH, estradiol, testosterone, SHBG and IGF1 levels were determined by immunoassays.
In all age groups, higher BMI (all 1 year age-groups, P ≤ 0.041) was found with early compared with late maturation, despite similar BIA-estimated body fat percentage (BIA-BF%). Neither BMI nor BIA-BF% differed for a given stage of maturation. BMI percentile-for-age and prevalence of overweight/obesity were higher in the early compared with late matured pubertal children (all P ≤ 0.038), despite similar BIA-BF%. Pubertal girls with BIA-BF >29% had significantly lower LH and FSH levels compared with normal-weight girls (P ≤ 0.041).
Early maturational timing was not associated with higher adiposity for a given stage of puberty. Using BMI percentile-for-age overestimated the degree of adiposity in early pubertal compared with late pubertal children.
青春期提前与青春期女孩的年龄别 BMI 百分位持续相关，而男孩的数据则更为模糊。然而，较高的年龄别 BMI 百分位可能是青春期提前本身的结果，而不是相反。本研究旨在评估肥胖标志物与健康青春期男孩和女孩的青春期时间和生殖激素水平的关系。
基于人群的横断面研究（哥本哈根青春期研究）。802 名健康的白种人儿童和青少年（486 名女孩）年龄在 8.5-16.5 岁之间。使用 BMI 和生物电阻抗分析（BIA）来估计肥胖程度。评估临床青春期标志物（Tanner 分期和睾丸体积）。通过免疫分析测定 LH、FSH、雌二醇、睾酮、SHBG 和 IGF1 水平。
在所有年龄组中，与晚期成熟相比，早期成熟的 BMI 更高（所有 1 岁年龄组，P≤0.041），尽管 BIA 估计的体脂百分比（BIA-BF%）相似。对于给定的成熟阶段，BMI 或 BIA-BF%没有差异。与晚期成熟的青春期儿童相比，早期成熟的青春期儿童的 BMI 年龄百分位和超重/肥胖的患病率更高（所有 P≤0.038），尽管 BIA-BF%相似。BIA-BF%>29%的青春期女孩的 LH 和 FSH 水平明显低于正常体重女孩（P≤0.041）。
对于给定的青春期阶段，早期成熟的时间与较高的肥胖程度无关。使用 BMI 年龄百分位比晚期青春期儿童高估了早期青春期的肥胖程度。
