补体激活与疾病严重程度相关，并在恶性疟原虫疟疾中促成细胞因子反应。
Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria.
作者信息
Berg Aase, Otterdal Kari, Patel Sam, Gonca Miguel, David Catarina, Dalen Ingvild, Nymo Stig, Nilsson Margareta, Nordling Sofia, Magnusson Peetra U, Ueland Thor, Prato Mauro, Giribaldi Giuliana, Mollnes Tom Eirik, Aukrust Pål, Langeland Nina, Nilsson Per H
机构信息
Department of Medicine, Stavanger University Hospital Department of Clinical Science, University of Bergen Department of Medicine, Central Hospital of Maputo, Mozambique.
Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet.
出版信息
J Infect Dis. 2015 Dec 1;212(11):1835-40. doi: 10.1093/infdis/jiv283. Epub 2015 May 15.
The impact of complement activation and its possible relation to cytokine responses during malaria pathology was investigated in plasma samples from patients with confirmed Plasmodium falciparum malaria and in human whole-blood specimens stimulated with malaria-relevant agents ex vivo. Complement was significantly activated in the malaria cohort, compared with healthy controls, and was positively correlated with disease severity and with certain cytokines, in particular interleukin 8 (IL-8)/CXCL8. This was confirmed in ex vivo-stimulated blood specimens, in which complement inhibition significantly reduced IL-8/CXCL8 release. P. falciparum malaria is associated with systemic complement activation and complement-dependent release of inflammatory cytokines, of which IL-8/CXCL8 is particularly prominent.
在确诊为恶性疟原虫疟疾的患者血浆样本以及体外受疟疾相关因子刺激的人全血样本中，研究了补体激活的影响及其在疟疾病理过程中与细胞因子反应的可能关系。与健康对照相比，疟疾队列中的补体被显著激活，并且与疾病严重程度以及某些细胞因子呈正相关，特别是白细胞介素8（IL-8）/CXCL8。这在体外刺激的血液样本中得到证实，其中补体抑制显著减少了IL-8/CXCL8的释放。恶性疟原虫疟疾与全身补体激活以及炎症细胞因子的补体依赖性释放有关，其中IL-8/CXCL8尤为突出。
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