West African Center for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.
Immunology. 2018 Apr;153(4):423-434. doi: 10.1111/imm.12877. Epub 2017 Dec 26.
Immunity to malaria could be categorized broadly as antiparasite or antidisease immunity. While most vaccine research efforts have focused on antiparasite immunity, the evidence from endemic populations suggest that antidisease immunity is an important component of natural immunity to malaria. The processes that mediate antidisease immunity have, however, attracted little to no attention, and most interests have been directed towards the antibody responses. This review evaluates the evidence for antidisease immunity in endemic areas and discusses the possible mechanisms responsible for it. Given the key role that inflammation plays in the pathogenesis of malaria, regulation of the inflammatory response appears to be a major mechanism for antidisease immunity in naturally exposed individuals.
疟疾免疫可大致分为抗寄生虫或抗疾病免疫。虽然大多数疫苗研究都集中在抗寄生虫免疫上，但来自流行地区的证据表明，抗疾病免疫是对疟疾自然免疫的一个重要组成部分。然而，介导抗疾病免疫的过程几乎没有引起关注，大多数关注点都集中在抗体反应上。本综述评估了流行地区抗疾病免疫的证据，并讨论了可能的机制。鉴于炎症在疟疾发病机制中发挥的关键作用，炎症反应的调节似乎是自然暴露个体抗疾病免疫的主要机制。
