Nagy G, Neill J D, Makara G B, Halász B
Second Department of Anatomy, Semmelweis Medical University, Budapest, Hungary.
Brain Res. 1989 Dec 11;504(1):165-7. doi: 10.1016/0006-8993(89)91618-1.
Suckling stimulus did not induce significant release of prolactin (PRL) in lactating homozygous Brattleboro rats, whereas it did it in heterozygous animals. Daily treatment of homozygous rats with vasopressin partly restored the PRL response to suckling. Findings suggest that vasopressin-neurophysin-glycopeptide precursor missing in homozygous Brattleboro rats may play a role in suckling-induced PRL release.
在哺乳期的纯合布拉特洛伯大鼠中，哺乳刺激并未诱导催乳素（PRL）的显著释放，而在杂合动物中则会诱导其释放。每天用加压素治疗纯合大鼠可部分恢复PRL对哺乳的反应。研究结果表明，纯合布拉特洛伯大鼠中缺失的加压素-神经垂体素-糖肽前体可能在哺乳诱导的PRL释放中起作用。
