Heller Lucie, Schwarz Stefan, Obernauer Anja, Csuk René
Martin-Luther-Universität Halle-Wittenberg, Bereich Organische Chemie, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
Martin-Luther-Universität Halle-Wittenberg, Bereich Organische Chemie, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
Bioorg Med Chem Lett. 2015 Jul 1;25(13):2654-6. doi: 10.1016/j.bmcl.2015.04.086. Epub 2015 May 5.
Ring opening of allobetulone gave either seco-acid 8 or di-acid 4. These acids were converted into esters that were screened by Ellman's assay. A dibutenylester of low cytotoxicity (NIH 3T3 murine embryonic fibroblasts) was shown to be a good mixed-type inhibitor (Ki=3.39, Ki'=2.26μM) for acetylcholinesterase.
别香橙酮的开环反应生成了裂环酸8或二酸4。这些酸被转化为酯，并通过埃尔曼测定法进行筛选。一种具有低细胞毒性（对NIH 3T3小鼠胚胎成纤维细胞）的二丁烯基酯被证明是乙酰胆碱酯酶的一种良好的混合型抑制剂（Ki = 3.39，Ki' = 2.26μM）。
