[Experimental study on the antigoiter effect of high casein nutrition].

In this experiment, goiter was successfully induced in rat with MMI, and the antigoiter effect of 25% and 50% casein diet was observed. The results showed that the diet with 50% casein is more effective than that with 25% casein in counteracting MMI and preventing goiter in rat. The antigoiter mechanisms of high protein nutrition might be as follows: Protecting the mechanism of thyroid iodine transportation through the follicular cell, and therefore accelerating thyroid iodine metabolism; Relieving thyroid peroxidase (TPO) from the inhibitive effect of MMI and facilitating thyroid hormone synthesis; Coordinating the function of hypothalamus-pituitary-TSH-thyroid axis and protecting the wholeness of thyroid cell and thus avoiding the occurrence of pathological changes.