Henze A, Freise J, Magerstedt P, Majewski A
Department for Gastroenterology and Hepatology, Medizinische Hochschule, Hannover.
Comput Med Imaging Graph. 1989 Nov-Dec;13(6):455-62. doi: 10.1016/0895-6111(89)90286-3.
Liposomes laden with radio-opaque agents (ROA) were prepared by the reverse phase evaporation method. The liposome solutions--containing 1.7-2.5 mg iodine per mg lipid--were injected into Wistar rats. 60 min post injection the rats were scanned in a Siemens CT scanner. Following the injection of 260 mg encapsulated iodine per kg bodyweight--less than half the iodine of the normal ROA bolus injection--there was a long lasting arise in liver enhancement of 40 Hounsfield units (HU). In animals with liver tumours induced by nitrosamine lesions of 2-3 mm in diameter could be detected.
