Li Gang, Xia Jiyi, Jia Peng, Zhao Jian, Sun Yuqin, Wu Changxue, Liu Bin
Department of Pediatrics, The Affiliated Hospital of Luzhou Medical College, No. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
Research Center for Drug and Functional Foods of Luzhou Medical College, Luzhou, 646000, Sichuan, China.
Pediatr Cardiol. 2015 Oct;36(7):1423-8. doi: 10.1007/s00246-015-1178-5. Epub 2015 May 17.
This study aims to estimate plasma levels of acylated ghrelin in children with pulmonary hypertension (PH) associated with congenital heart disease (CHD) and to correlate the levels of acylated ghrelin with endothelin-1 (ET-1), nitric oxide (NO), and clinical hemodynamic parameters. We investigated the plasma concentration of acylated ghrelin, ET-1, NO, and the hemodynamic parameters in 20 children with CHD, 20 children with PH-CHD, and 20 normal children. Plasma-acylated ghrelin and NO levels were significantly higher in CHD group than in control subjects (P < 0.001). Moreover, plasma-acylated ghrelin, ET-1, and NO levels were significantly elevated in PH-CHD group compared with the CHD group (P < 0.05). In PH-CHD children, plasma-acylated ghrelin levels correlated positively with pulmonary artery systolic pressure (PASP; r = 0.740, P < 0.001), pulmonary artery diastolic pressure (PADP; r = 0.613, P = 0.004), right ventricular systolic pressure (RVSP; r = 0.642, P = 0.002), mean pulmonary arterial hypertension (mPAP; r = 0.685, P = 0.001), right ventricle diameter (RVD; r = 0.473, P = 0.035), pulmonary artery trunk diameter (PAD; r = 0.613, P = 0.004), NO (r = 0.463, P = 0.04), and ET-1 (r = 0.524, P = 0.018). Plasma-acylated ghrelin levels were elevated both in CHD and in PH-CHD. Increased acylated ghrelin levels correlated positively with ET-1, NO, PASP, PADP, RVSP, mPAP, RVD, and PAD. Acylated ghrelin may be a new biomarker of PH-CHD.
本研究旨在评估先天性心脏病（CHD）相关肺动脉高压（PH）患儿的酰基化胃饥饿素血浆水平，并将酰基化胃饥饿素水平与内皮素-1（ET-1）、一氧化氮（NO）及临床血流动力学参数进行关联分析。我们调查了20例CHD患儿、20例PH-CHD患儿及20例正常儿童的酰基化胃饥饿素、ET-1、NO血浆浓度及血流动力学参数。CHD组的血浆酰基化胃饥饿素和NO水平显著高于对照组（P < 0.001）。此外，与CHD组相比，PH-CHD组的血浆酰基化胃饥饿素、ET-1和NO水平显著升高（P < 0.05）。在PH-CHD患儿中，血浆酰基化胃饥饿素水平与肺动脉收缩压（PASP；r = 0.740，P < 0.001）、肺动脉舒张压（PADP；r = 0.613，P = 0.004）、右心室收缩压（RVSP；r = 0.642，P = 0.002）、平均肺动脉压（mPAP；r = 0.685，P = 0.001）、右心室直径（RVD；r = 0.473，P = 0.035）、肺动脉干直径（PAD；r = 0.613，P = 0.004）、NO（r = 0.463，P = 0.04）及ET-1（r = 0.524，P = 0.018）呈正相关。CHD和PH-CHD患儿的血浆酰基化胃饥饿素水平均升高。酰基化胃饥饿素水平升高与ET-1、NO、PASP、PADP、RVSP、mPAP、RVD及PAD呈正相关。酰基化胃饥饿素可能是PH-CHD的一种新生物标志物。
