Ophir R, Pecht M, Halperin D, Rashid G, Burstein Y, Ben-Efraim S, Trainin N
Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Israel.
Cancer Immunol Immunother. 1989;30(2):119-25. doi: 10.1007/BF01665963.
The effect of the thymic hormone, THF-gamma 2, on the immunocompetence of 5-fluorouracil (5-FU)-treated BALB/c mice, bearing MOPC-315 tumor, was examined. Treatment of noninoculated or tumor-bearing mice with THF-gamma 2 after 5-FU injection, resulted in an increase in the antibody response to sheep red blood cells and in the allogeneic response in spleen cell cultures and had no effect on the concanavalin-A-induced interleukin-2 secretion beyond that caused by 5-FU alone. Treatment with either 5-FU alone or 5-FU and THF-gamma 2 resulted in restoration to normal values of Lyt1- and L3T4-positive populations in tumor-bearing mice. THF-gamma 2 prolonged the survival time of mice bearing MOPC-315 tumor beyond that observed in mice treated with 5-FU alone.
研究了胸腺激素THF-γ2对荷MOPC-315肿瘤的5-氟尿嘧啶（5-FU）处理的BALB/c小鼠免疫能力的影响。在5-FU注射后用THF-γ2处理未接种或荷瘤小鼠，导致对绵羊红细胞的抗体反应增加以及脾细胞培养中的同种异体反应增加，并且对伴刀豆球蛋白A诱导的白细胞介素-2分泌的影响不超过单独使用5-FU所引起的影响。单独使用5-FU或5-FU与THF-γ2联合处理导致荷瘤小鼠中Lyt1和L3T4阳性群体恢复到正常水平。THF-γ2延长了荷MOPC-315肿瘤小鼠的存活时间，超过了单独用5-FU处理的小鼠。
