Wang Yinyan, Liu Shuai, Fan Xing, Li Shaowu, Wang Renzhi, Wang Lei, Ma Jun, Jiang Tao, Ma Wenbin
Beijing Neurosurgical Institute, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China.
J Neurooncol. 2015 Jun;123(2):299-306. doi: 10.1007/s11060-015-1798-x. Epub 2015 May 16.
Both age of patients and tumor location are associated with tumor origin, genetic characteristics, and prognosis. The objective of this study was to investigate the relationship between tumor location and age at diagnosis in a large cohort of patients with a primary diagnosis of glioma. We consecutively enrolled a cohort of 200 adults with glioblastoma and another cohort of 200 adults with diffuse low-grade gliomas. The magnetic resonance images of all tumors were manually segmented and then registered to a standard brain space. By using voxel-by-voxel regression analysis, specific brains regions associated with advanced age at tumor diagnosis were localized. In the low-grade gliomas cohort, the brain regions associated with advanced age at tumor diagnosis were mainly located in the right middle frontal region, while a region in the left temporal lobe, particularly at the subgranular zone, was associated with lower age at tumor diagnosis. In the glioblastoma cohort, the brain regions associated with advanced age at tumor diagnosis were mainly located in the temporal lobe, particularly at the posterior region of the subventricular zones. A region in the left inferior frontal region was associated with lower age at tumor diagnosis. Significant differences in the age of patients were found between tumors located in the identified regions and those located elsewhere in both cohorts. The current study demonstrated the correlation between tumor location and age at diagnosis, which implies differences in the origin of gliomas in young and older patients.
患者年龄和肿瘤位置均与肿瘤起源、基因特征及预后相关。本研究的目的是在一大群原发性胶质瘤患者中调查肿瘤位置与诊断时年龄之间的关系。我们连续纳入了一组200例成胶质细胞瘤患者和另一组200例弥漫性低级别胶质瘤患者。对所有肿瘤的磁共振图像进行手动分割，然后配准到标准脑空间。通过逐体素回归分析，定位了与肿瘤诊断时高龄相关的特定脑区。在低级别胶质瘤队列中，与肿瘤诊断时高龄相关的脑区主要位于右侧额中回，而左侧颞叶的一个区域，特别是颗粒下区，与肿瘤诊断时较低年龄相关。在成胶质细胞瘤队列中，与肿瘤诊断时高龄相关的脑区主要位于颞叶，特别是脑室下区后部。左侧额下回的一个区域与肿瘤诊断时较低年龄相关。在两个队列中，位于所确定区域的肿瘤与位于其他部位的肿瘤之间，患者年龄存在显著差异。当前研究证明了肿瘤位置与诊断时年龄之间的相关性，这意味着年轻和老年患者胶质瘤起源存在差异。
