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[特发性膜性肾小球肾炎。临床形态学关系及预后]

[Idiopathic membranous glomerulonephritis. Clinico-morphologic relations and prognosis].

作者信息

Matousovic K, Rossmann P, Prát V, Skibová J, Drevíkovská J

出版信息

Cas Lek Cesk. 1989 Oct 27;128(43-44):1377-81.

PMID:2598253
Abstract

Membranous glomerulonephritis (GN) was diagnosed in 61 of 993 patients with histologically confirmed primary GN. Two-thirds of the patients were men. High hypertension was recorded in 7.5% of the patients. A typical finding was marked proteinuria (6.15 +/- 4.88 g/24 h.) with mild erythrocyturia (median 8 million in Addis sediment). At the time of biopsy 86% of the patients had normal creatininaemia, the level of which was positively correlated with the blood pressure and degree of tubulointerstitial regression. The cumulative duration of renal function in 5, 10 and 20 years was 88, 80 and 57%; during the same time intervals 22, 48 and 52% of the patients were cured.

摘要

在993例经组织学确诊的原发性肾小球肾炎(GN)患者中,有61例被诊断为膜性肾小球肾炎。三分之二的患者为男性。7.5%的患者有重度高血压。典型表现为显著蛋白尿(6.15±4.88g/24小时)伴轻度红细胞尿(阿迪斯计数中位数为800万)。活检时86%的患者肌酐血症正常,肌酐水平与血压及肾小管间质退变程度呈正相关。肾功能在5年、10年和20年时的累积保留率分别为88%、80%和57%;在相同时间间隔内,22%、48%和52%的患者病情缓解。

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