手性、高官能化环戊烷的制备及其在前列腺素E1合成中的应用。
Preparation of chiral, highly functionalized cyclopentanes and its application to the synthesis of prostaglandin E1.
作者信息
Okano K, Suemune H, Sakai K
出版信息
Chem Pharm Bull (Tokyo). 1989 Aug;37(8):1995-8. doi: 10.1248/cpb.37.1995.
PMID:2598306
Abstract
This paper describes the preparation of the polyfunctionalized cyclopentane ((+/-)-5) by silica gel-catalyzed air-oxidation, and its kinetic resolution by means of microbial reduction with Rhodotorula rubra to afford optically pure (-)-5 (greater than 99% ee). Starting with (-)-5, a new route to prostaglandin E1 was established.
摘要
本文描述了通过硅胶催化空气氧化制备多官能化环戊烷（(±)-5），以及通过红酵母微生物还原进行动力学拆分以得到光学纯的(-)-5（对映体过量大于99%）的方法。从(-)-5出发，建立了一条合成前列腺素E1的新路线。
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