Imai T, Nishiyama T, Ueno M, Otagiri M
Chem Pharm Bull (Tokyo). 1989 Aug;37(8):2251-2. doi: 10.1248/cpb.37.2251.
The dissolution behavior of several acidic and basic drugs from kneaded mixtures with water-soluble gelatin have been studied in comparison with that of the drug alone. The results revealed a significant increase of dissolution rate of drugs from kneaded mixtures. The water-soluble gelatin showed little interaction with any of the drugs in solution or in the solid state. Interestingly, the contact angle of the kneaded mixture was remarkably decreased compared with that of the drug powder and was found to be almost the same as that of water-soluble gelatin powder. Thus, the enhanced dissolution rate of the drug caused by water-soluble gelatin was explained by the improvement of wettability of the drug by water.
与单独的药物相比，已经研究了几种酸性和碱性药物从与水溶性明胶捏合的混合物中的溶出行为。结果表明，捏合混合物中药物的溶出速率显著增加。水溶性明胶在溶液或固态下与任何一种药物的相互作用都很小。有趣的是，与药物粉末相比，捏合混合物的接触角显著降低，并且发现与水溶性明胶粉末的接触角几乎相同。因此，水溶性明胶引起的药物溶出速率提高可以用水对药物润湿性的改善来解释。
