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一名慢性铁过载血液透析患者接受去铁胺治疗后发生嗜水气单胞菌败血症伴脓毒性栓塞和横纹肌溶解。

Aeromonas hydrophila sepsis with septic embolism and rhabdomyolysis in a chronic iron overload haemodialysis patient treated with deferoxamine.

作者信息

Chompoonuch Supachat, Wangsomboonsiri Wittaya, Wongprasit Pawinee, Sungkanuparph Somnuek, Phakdeekitcharoen Bunyong

机构信息

Department of Medicine.

Division of Infectious Diseases.

出版信息

NDT Plus. 2009 Aug;2(4):303-5. doi: 10.1093/ndtplus/sfp029. Epub 2009 Mar 6.

Abstract

Aeromonas infection in humans is associated with certain underlying diseases, especially chronic liver disease or malignancy. However, Aeromonas infection associated with iron overload is rarely reported. We report a case of a 47-year-old female with end-stage renal disease on haemodialysis and on deferoxamine treatment for iron overload who developed Aeromonas sepsis with septic embolism and rhabdomyolysis. Although the patients with Aeromonas infection and rhabdomyolysis have been correlated with high mortality, this reported case survived. We suggest that a chronic haemodialysis patient on deferoxamine treatment for iron overload is vulnerable to Aeromonas infection. In such cases, the clinician should be alerted to the possibility of rhabdomyolsis, and frequent haemodialysis is necessary.

摘要

人类气单胞菌感染与某些基础疾病相关,尤其是慢性肝病或恶性肿瘤。然而,与铁过载相关的气单胞菌感染鲜有报道。我们报告一例47岁女性终末期肾病患者,该患者正在接受血液透析且因铁过载接受去铁胺治疗,其发生了伴有脓毒性栓塞和横纹肌溶解的气单胞菌败血症。尽管气单胞菌感染合并横纹肌溶解的患者死亡率较高,但该报道病例存活了下来。我们认为,因铁过载接受去铁胺治疗的慢性血液透析患者易受气单胞菌感染。在这种情况下,临床医生应警惕横纹肌溶解的可能性,且有必要增加血液透析频率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624f/4421254/3bd97ba8fc78/sfp029fig1.jpg

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