Okosun I S, Seale J P, Lyn R
Division of Epidemiology & Biostatistics, School of Public Health, Georgia State University, Atlanta, GA, USA.
Department of Family Medicine, Medical Center of Central Georgia and Mercer University School of Medicine, Macon, GA, USA.
Nutr Diabetes. 2015 May 18;5(5):e155. doi: 10.1038/nutd.2015.5.
To determine the independent and commingling effect of android and gynoid percent fat (measured using Dual Energy X-Ray Absorptiometry) on cardiometabolic dysregulation in normal weight American adults.
The 2005-2006 data (n=1802) from the United States National Health and Nutritional Examination Surveys (NHANES) were used in this study. Associations of android percent fat, gynoid percent fat and their joint occurrence with risks of cardiometabolic risk factors were estimated using prevalence odds ratios from logistic regression analyses.
Android-gynoid percent fat ratio was more highly correlated with cardiometabolic dysregulation than android percent fat, gynoid percent fat or body mass index. Commingling of android and gynoid adiposities was associated with much greater odds of cardiometabolic risk factors than either android or gynoid adiposities. Commingling of android and gynoid adiposities was associated with 1.75 (95% confidence interval (CI)=1.42-2.93), 1.48 (95% CI=1.32-1.91), 1.61 (95% CI=1.50-1.89), 3.56 (95% CI=2.91-4.11) and 1.86 (95% CI=1.49-1.96) increased odds of elevated glucose, elevated blood pressure, elevated low-density lipoprotein-cholesterol, elevated triglyceride and low high-density lipoprotein-cholesterol, respectively.
Normal weight subjects who present with both android and gynoid adiposities should be advised of the associated health risks. Both android and gynoid fat accumulations should be considered in developing public health strategies for reducing cardiometabolic disease risk in normal weight subjects.
确定男性型和女性型脂肪百分比（使用双能X线吸收法测量）对正常体重美国成年人心脏代谢失调的独立及混合影响。
本研究使用了美国国家健康与营养检查调查（NHANES）2005 - 2006年的数据（n = 1802）。采用逻辑回归分析的患病率比值比来估计男性型脂肪百分比、女性型脂肪百分比及其共同出现与心脏代谢危险因素风险之间的关联。
男性型与女性型脂肪百分比比值与心脏代谢失调的相关性高于男性型脂肪百分比、女性型脂肪百分比或体重指数。男性型和女性型肥胖的混合与心脏代谢危险因素的几率增加显著相关，高于单独的男性型或女性型肥胖。男性型和女性型肥胖的混合与血糖升高、血压升高、低密度脂蛋白胆固醇升高、甘油三酯升高和高密度脂蛋白胆固醇降低的几率增加分别相关，比值比为1.75（95%置信区间（CI）= 1.42 - 2.93）、1.48（95% CI = 1.32 - 1.91）、1.61（95% CI = 1.50 - 1.89）、3.56（95% CI = 2.91 - 4.11）和1.86（95% CI = 1.49 - 1.96）。
对于同时存在男性型和女性型肥胖的正常体重受试者，应告知其相关健康风险。在制定降低正常体重受试者心脏代谢疾病风险的公共卫生策略时，应同时考虑男性型和女性型脂肪堆积。
