Impact of pharmaceutical excipients on in vitro association of saquinavir to chylomicrons.
作者信息
Ro J, Kim H, Hwang S H, Yun G, Lee J
出版信息
Pharmazie. 2014 Oct;69(10):745-6.
PMID:25985563
Abstract
This study was performed to investigate the impact of pharmaceutical excipients commonly used for lymphatic transport on in vitro drug association with chylomicrons (CM). A CM association study was conducted using saquinavir solubilized in four different pharmaceutical excipients. We observed a linear relationship between saquinavir solubility and drug association, suggesting that the solubility of saquinavir in excipients is a key determinant for successful lymphatic delivery. Broadly, these results suggest that excipients with good solubilization properties may be advantageous for enhancing lymphatic drug delivery.
摘要
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