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[富含来自脂肪抽吸物的同种异体冷冻保存干细胞的脂肪移植物异位移植的特点]

[Peculiarities of heterotopic transplantation of adipose graft enriched by allogeneic cryopreserved stem cells from adipose lipoaspirate].

作者信息

Usenko O Yu, Salyutin R V, Zapohlska K M, Palyanytsya S S, Panchenko L A

出版信息

Klin Khir. 2015 Feb(2):76-8.

Abstract

Possibilities of application of the donor cryoconserved cellular material (mesenchymal stem cells, obtained from adipose tissue) for defense of transplanted adipose graft from the tissue resorption were studied. The adipose graft enrichment, using cryoconserved allogenic mesenchymal multipotent stem cells, obtained from adipose tissue, caused activation of destructive-inflammatory processes in adipose graft, the adipocytes survival worsening, and in further--the transplant mass deficiency. We suggest inexpedient to apply in clinical practice the donor cryoconserved stem cells for defense of transplanted adipose tissue from the tissue resorption.

摘要

研究了供体低温保存的细胞材料(从脂肪组织中获得的间充质干细胞)用于保护移植的脂肪移植物免受组织吸收的可能性。使用从脂肪组织中获得的低温保存的同种异体间充质多能干细胞对脂肪移植物进行富集,会导致脂肪移植物中破坏性炎症过程的激活、脂肪细胞存活情况恶化,进而导致移植块体积不足。我们认为在临床实践中应用供体低温保存的干细胞来保护移植的脂肪组织免受组织吸收是不合适的。

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