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结直肠癌肝肺转移的介入肿瘤学:当前的技术水平

Interventional oncology for liver and lung metastases from colorectal cancer: The current state of the art.

作者信息

de Baere T, Tselikas L, Pearson E, Yevitch S, Boige V, Malka D, Ducreux M, Goere D, Elias D, Nguyen F, Deschamps F

机构信息

Gustave-Roussy Cancer Campus, Institut Gustave-Roussy, 112, rue Édouard-Vaillant, 94805 Villejuif, France.

Gustave-Roussy Cancer Campus, Institut Gustave-Roussy, 112, rue Édouard-Vaillant, 94805 Villejuif, France.

出版信息

Diagn Interv Imaging. 2015 Jun;96(6):647-54. doi: 10.1016/j.diii.2015.04.004. Epub 2015 May 16.

DOI:10.1016/j.diii.2015.04.004
PMID:25985998
Abstract

Interventional oncology is developing rapidly as a result of advances in imaging and medical devices. Although the treatments offered are recent and not yet fully validated in the guidelines, they allow non-invasive curative treatments to be offered to a growing number of patients. When it is used in a highly selected patients with less than three metastases under 2-3cm in size, percutaneous tumor ablation offers local efficacy similar to excision surgery with considerable sparing of the parenchyma, both for lung and liver metastases. Hepatic intra-arterial therapies (chemotherapy, radioembolization, and chemoembolization) are now "salvage" methods after chemotherapy has failed and are being assessed in earlier lines of treatment.

摘要

由于成像技术和医疗设备的进步,介入肿瘤学正在迅速发展。尽管所提供的治疗方法是新出现的,尚未在指南中得到充分验证,但它们使越来越多的患者能够接受非侵入性的根治性治疗。当用于高度选择的、转移灶少于三个且大小在2 - 3厘米以下的患者时,经皮肿瘤消融术在局部疗效上与切除手术相似,对肺和肝转移灶的实质组织有相当程度的保留。肝动脉内治疗(化疗、放射性栓塞和化学栓塞)目前是化疗失败后的“挽救”方法,并且正在早期治疗阶段进行评估。

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引用本文的文献

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J Gastrointest Cancer. 2016 Sep;47(3):223-31. doi: 10.1007/s12029-016-9818-4.
2
Robust evidence for long-term survival with Y radioembolization in chemorefractory liver-predominant metastatic colorectal cancer.Y 放射性栓塞治疗化疗抵抗性肝优势转移性结直肠癌长期生存的有力证据。
Eur Radiol. 2017 Jan;27(1):113-119. doi: 10.1007/s00330-016-4345-z. Epub 2016 Apr 8.