Ensari Ipek, Adamson Brynn C, Motl Robert W
University of Illinois at Urbana-Champaign, USA.
J Health Psychol. 2016 Nov;21(11):2732-2741. doi: 10.1177/1359105315584837. Epub 2016 Jul 10.
Worsening depressive symptoms and walking impairment are significant burdens in multiple sclerosis. We explored the reciprocal relationship between depressive symptoms and walking impairment in a cohort of 269 people with relapsing-remitting multiple sclerosis over 2 years. The data were examined using longitudinal panel analysis in Mplus. Baseline depressive symptoms predicted change in walking impairment at 1-year follow-up (path coefficient = .074), and change in walking impairment at 1-year follow-up predicted change in depressive symptoms at 2-year follow-up (path coefficient = .177). Our study provides preliminary evidence for initiation of a reciprocal relationship between depressive symptoms and walking impairment in relapsing-remitting multiple sclerosis.
抑郁症状加重和行走功能障碍是多发性硬化症的重大负担。我们在一个由269例复发缓解型多发性硬化症患者组成的队列中，对其抑郁症状和行走功能障碍之间的相互关系进行了为期2年的探究。数据采用Mplus中的纵向面板分析进行检验。基线抑郁症状可预测1年随访时行走功能障碍的变化（路径系数 = 0.074），而1年随访时行走功能障碍的变化可预测2年随访时抑郁症状的变化（路径系数 = 0.177）。我们的研究为复发缓解型多发性硬化症中抑郁症状和行走功能障碍之间相互关系的启动提供了初步证据。
