Department of Food Science, University of Wisconsin-Madison, 1605 Linden Dr, Madison, WI 53706, USA.
Food Funct. 2015 Jun;6(6):1773-86. doi: 10.1039/c5fo00202h.
Crohn's disease and ulcerative colitis presently have no cure and are treated with anti-inflammatory drugs or monoclonal antibodies targeting pro-inflammatory cytokines. A variety of rodent models have been used to model chronic and acute colitis. Dietary polyphenols in foods and botanicals are of considerable interest for prevention and treatment of colitis. Many dietary polyphenols have been utilized for prevention of colitis in rodent models. Berries, green tea polyphenols, curcumin, and stilbenes have been the most extensively tested polyphenols in rodent models of colitis. The majority of polyphenols tested have inhibited colitis in rodents, but increasing doses of EGCG and green tea, isoflavones, flaxseed, and α-mangostin have exacerbated colitis. Few studies have examined combination of polyphenols or other bioactives for inhibition of colitis. Translating polyphenol doses used in rodent models of colitis to human equivalent doses reveals that supplemental doses are most likely required to inhibit colitis from a single polyphenol treatment. The ability to translate polyphenol treatments in rodent models is likely to be limited by species differences in xenobiotic metabolism and microbiota. Given these limitations, data from polyphenols in rodent models suggests merit for pursuing additional clinical studies for prevention of colitis.
目前，克罗恩病和溃疡性结肠炎尚无治愈方法，其治疗方法是使用抗炎药物或针对促炎细胞因子的单克隆抗体。已经使用了多种啮齿动物模型来模拟慢性和急性结肠炎。食物和植物中的膳食多酚对于预防和治疗结肠炎具有重要意义。许多膳食多酚已被用于预防结肠炎的啮齿动物模型中。浆果、绿茶多酚、姜黄素和白藜芦醇是在结肠炎啮齿动物模型中研究最多的多酚。大多数经过测试的多酚都可以抑制结肠炎，但 EGCG 和绿茶、异黄酮、亚麻籽和α-倒捻子素的剂量增加会加重结肠炎。很少有研究检查多酚或其他生物活性物质联合抑制结肠炎。将结肠炎啮齿动物模型中使用的多酚剂量转化为人类等效剂量表明，从单一多酚治疗中抑制结肠炎很可能需要补充剂量。将多酚治疗转化为啮齿动物模型的能力可能受到异生物质代谢和微生物组中种间差异的限制。考虑到这些限制，来自啮齿动物模型中多酚的研究数据表明，有必要进一步进行临床研究以预防结肠炎。
