Nguemo Joseph Djiometio, O'Neill Tyler J, Kou Nancy, Tynan Anne-Marie, Agha Ayda, Burchell Ann N, Antoniou Tony
Department of Family and Community Medicine, St. Michael's Hospital, 410 Sherbourne Street - 4th Floor, Toronto, Ontario, M4X 1K2, Canada.
Ontario HIV Treatment Network, Toronto, Ontario, Canada.
Syst Rev. 2015 May 19;4:72. doi: 10.1186/s13643-015-0054-y.
As persons with HIV live longer, data regarding the epidemiology of colorectal cancer are required to optimize the long-term management of these patients. The purpose of this systematic review and meta-analysis is to synthesize evidence regarding the incidence of colorectal cancer in persons with HIV.
METHODS/DESIGN: Our primary outcome is the standardized incidence ratio of colorectal cancer among persons with HIV relative to rates in persons not living with HIV. Our secondary objectives are to summarize the evidence for differences with respect to stage at diagnosis, site of disease, and mortality due to colorectal cancer. We will search electronic bibliographic databases from their inception date, as well as conference proceedings and reference lists of included articles. Two investigators will independently screen citations and full-text articles, conduct data abstraction, and appraise study quality. We will examine clinical, methodological, and statistical heterogeneity among studies prior to conducting meta-analysis. Random effects meta-analysis methods will be employed to estimate standardized incidence ratios. These data will inform the development of guidelines for colorectal cancer screening in persons with HIV.
PROSPERO CRD42014013449.
随着艾滋病毒感染者寿命延长，需要有关结直肠癌流行病学的数据来优化这些患者的长期管理。本系统评价和荟萃分析的目的是综合关于艾滋病毒感染者结直肠癌发病率的证据。
方法/设计：我们的主要结局是艾滋病毒感染者中结直肠癌的标准化发病率与未感染艾滋病毒者的发病率之比。我们的次要目标是总结关于诊断分期、疾病部位以及结直肠癌死亡率差异的证据。我们将从其起始日期开始检索电子文献数据库，以及会议论文集和纳入文章的参考文献列表。两名研究人员将独立筛选文献和全文文章，进行数据提取，并评估研究质量。在进行荟萃分析之前，我们将检查研究之间的临床、方法学和统计学异质性。将采用随机效应荟萃分析方法来估计标准化发病率。这些数据将为制定艾滋病毒感染者结直肠癌筛查指南提供依据。
PROSPERO CRD42014013449。
