果蝇钠通道1（DSC1）：电压门控阳离子通道新家族的创始成员。
The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels.
作者信息
Dong Ke, Du Yuzhe, Rinkevich Frank, Wang Lingxin, Xu Peng
机构信息
Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, MI 48824, USA.
Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, MI 48824, USA.
出版信息
Pestic Biochem Physiol. 2015 May;120:36-9. doi: 10.1016/j.pestbp.2014.12.005. Epub 2014 Dec 9.
It has been nearly three decades since the identification of the Drosophila Sodium Channel 1 (DSC1) gene from Drosophila melanogaster. The orthologs of the DSC1 gene have now been identified in other insect species including BSC1 from Blattella germanica. Functional analyses of DSC1/BSC1 channels in Xenopus oocytes reveal that DSC1 and BSC1 encode voltage-gated cation channels that are more permeable to Ca(2+) than to Na(+). Genetic and electrophysiological analyses show that knockout of the DSC1 gene in D. melanogaster causes behavioral and neurological modifications. In this review, we summarize major findings from recent studies and highlight a unique role of the DSC1 channel, distinct from that of the sodium channel, in regulating membrane excitability and modulating toxicity of pyrethroid insecticides.
自从黑腹果蝇中鉴定出果蝇钠通道1（DSC1）基因以来，已经过去了近三十年。现在，在包括德国小蠊的BSC1在内的其他昆虫物种中也鉴定出了DSC1基因的直系同源物。在非洲爪蟾卵母细胞中对DSC1/BSC1通道进行的功能分析表明，DSC1和BSC1编码对Ca(2+)的通透性比对Na(+)更高的电压门控阳离子通道。遗传和电生理分析表明，黑腹果蝇中DSC1基因的敲除会导致行为和神经学上的改变。在这篇综述中，我们总结了近期研究的主要发现，并强调了DSC1通道在调节膜兴奋性和调节拟除虫菊酯类杀虫剂毒性方面与钠通道不同的独特作用。
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