Cai Michael M X, Smith Edward R, Holt Stephen G
Department of Nephrology, Royal Melbourne Hospital , Melbourne, Victoria, Australia ; Department of Medicine (RMH), University of Melbourne , Melbourne, Victoria, Australia.
Department of Nephrology, Royal Melbourne Hospital , Melbourne, Victoria, Australia.
Bonekey Rep. 2015 May 6;4:672. doi: 10.1038/bonekey.2015.39. eCollection 2015.
Calcium and phosphate are the principle ions involved in the deposition of mineral in the human body. Inhibitors of mineralisation are essential for the prevention of ectopic mineral precipitation and deposition. In the past decade, through in vitro, in vivo and clinical observation studies, we have come to appreciate the importance of fetuin-A (Fet-A), a circulating glycoprotein, in preventing ectopic calcium phosphate mineralisation. Moreover, the detection of Fet-A-containing mineral complex, termed calciprotein particles (CPPs), has provided new ways to assess an individual's calcific risk. The pathophysiological significance of CPPs in disease states is yet to be defined, but it provides an exciting avenue to further our understanding of the development of ectopic mineralisation.
钙和磷是人体中参与矿物质沉积的主要离子。矿化抑制剂对于预防异位矿物质沉淀和沉积至关重要。在过去十年中，通过体外、体内和临床观察研究，我们逐渐认识到胎球蛋白-A（Fet-A），一种循环糖蛋白，在预防异位磷酸钙矿化中的重要性。此外，对含Fet-A的矿物质复合物，即钙蛋白颗粒（CPPs）的检测，为评估个体的钙化风险提供了新方法。CPPs在疾病状态下的病理生理意义尚未明确，但它为进一步理解异位矿化的发展提供了一条令人兴奋的途径。
