Bech Per, Lindberg Lone
Psychiatric Research Unit , Psychiatric Centre North Zealand , University of Copenhagen , Denmark.
Oxf Med Case Reports. 2014 Aug 28;2014(5):100-1. doi: 10.1093/omcr/omu039. eCollection 2014 Aug.
In a register study on patients hospitalized in the 1950s for anxiety neurosis, going until 1994 for diagnostic behaviour and until 2004 for suicidal behaviour, we found a co-existence with depression. However, the study has no information about therapy. Just after the finalization of this study, one of the patients was hospitalized in our department for depression. At that time the patient was 70 years old; at his index hospitalization in 1954 he was 30 years of age. Throughout his 40 years of illness he had received no psychiatric treatment. The spontaneous course went from panic attacks through stages of phobia and avoidance behaviour until the final stage of depression. At 70 years of age, for the first time in his life, he received antidepressant medication in the form of a specific serotonin re-uptake inhibitor. After 6 weeks of therapy not only the depression but also the anxiety disorder remitted.
在一项针对20世纪50年代因焦虑性神经症住院患者的登记研究中，随访至1994年观察诊断行为，至2004年观察自杀行为，我们发现焦虑性神经症与抑郁症共存。然而，该研究没有关于治疗的信息。就在这项研究结束后，其中一名患者因抑郁症住进了我们科室。当时该患者70岁；他在1954年首次住院时30岁。在他患病的40年里，他从未接受过精神科治疗。其自然病程从惊恐发作开始，经历恐惧症和回避行为阶段，直至最终的抑郁阶段。70岁时，他生平第一次接受了以特异性5-羟色胺再摄取抑制剂形式的抗抑郁药物治疗。经过6周的治疗，不仅抑郁症，而且焦虑症也得到了缓解。
