van der Linden J W M, Arendrup M C, Warris A, Lagrou K, Pelloux H, Hauser P M, Chryssanthou E, Mellado E, Kidd S E, Tortorano A M, Dannaoui E, Gaustad P, Baddley J W, Uekötter A, Lass-Flörl C, Klimko N, Moore C B, Denning D W, Pasqualotto A C, Kibbler C, Arikan-Akdagli S, Andes D, Meletiadis J, Naumiuk L, Nucci M, Melchers W J G, Verweij P E
Emerg Infect Dis. 2015 Jun;21(6):1041-4. doi: 10.3201/eid2106.140717.
To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.
为了调查临床分离曲霉菌株对唑类药物的耐药性，我们开展了一项前瞻性多中心国际监测。来自19个国家的22个中心共筛查了3788株曲霉菌株。结果发现，耐唑类药物的烟曲霉比之前认知的更为常见（患病率为3.2%），可导致耐药性侵袭性和非侵袭性曲霉病，并严重影响唑类药物的临床应用。
