口服N-乙酰半胱氨酸含片在人体中的生物利用度。
Bioavailability of suckable tablets of oral N-acetylcysteine in man.
作者信息
De Bernardi di Valserra M, Mautone G, Barindelli E, Lualdi P, Feletti F, Galmozzi M R
机构信息
Istituto di Farmacologia Medica II, Università degli Studi di Pavia, Italy.
出版信息
Eur J Clin Pharmacol. 1989;37(4):419-21. doi: 10.1007/BF00558514.
PMID:2598977
Abstract
The pharmacokinetics and bioavailability of suckable tablets and granules of N-acetylcysteine (NAC) have been compared after oral administration of 400 mg doses to 10 healthy volunteers. The oral bioavailability of the NAC tablets was 103%. In a multiple dosing study of the same tablets in the same subjects, a high maintenance plasma level of NAC was revealed.
摘要
在对10名健康志愿者口服400毫克剂量的N-乙酰半胱氨酸（NAC）后，对其可咀嚼片和颗粒剂的药代动力学和生物利用度进行了比较。NAC片剂的口服生物利用度为103%。在同一受试者中对相同片剂进行的多次给药研究中，发现NAC的维持血浆水平较高。
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