[The effect of dopamine on the systemic hemodynamic indices, on the blood supply of an ischemic focus and on the plasma enzyme activity in dogs with acute coronary occlusion].

In acute experiments on anesthetized dogs dopamine (10 micrograms/kg and 10 micrograms/kg/min) was shown to increase significantly the blood supply to ischemic regions and the minute heart volume at the background of insignificant systemic hypotension and tachycardia. When administered in a dose of 10 micrograms/kg/min dopamine increased the magnitude of the ratio of glycogen-phosphorylase b activity to total glycogen-phosphorylase activity in the blood plasma. Administration of 20 micrograms/kg of the drug did not produce a significant increase of the blood supply to ischemic regions and the minute heart volume in the presence of the tendency toward systemic hypotension and bradycardia.