Sysoliatina N A, Tomilenko V I
Farmakol Toksikol. 1989 Sep-Oct;52(5):28-31.
The binding of 3H-dihydroalprenolol and 3H-quinuclidinyl benzylate to lysosomes of the rat ventricular myocardium vas studied. More than one type of specific binding sites of dihydroalprenolol and quinuclidinyl benzylate at the rat myocardium lysosomes were found. The association constants values differ from the known values of the association constants of the same ligands with plasmatic membranes of the mammalian myocardium.
研究了3H-二氢阿普洛尔和3H-喹核醇基苯甲酸酯与大鼠心室心肌溶酶体的结合。发现二氢阿普洛尔和喹核醇基苯甲酸酯在大鼠心肌溶酶体上存在不止一种类型的特异性结合位点。其缔合常数的值与相同配体与哺乳动物心肌质膜的缔合常数已知值不同。
