使用免疫珠试验检测不育夫妇男性伴侣体内的精子结合抗体。

Detection of sperm-bound antibodies in the male partners of infertile couples using the immunobead test.

作者信息

Gregoriou O, Vitoratos N, Legakis N, Gregoriou G, Zourlas P A

机构信息

Second Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece.

出版信息

Eur J Obstet Gynecol Reprod Biol. 1989 Dec;33(3):235-9. doi: 10.1016/0028-2243(89)90135-4.

DOI:10.1016/0028-2243(89)90135-4

PMID:2599253

Abstract

The aim of this investigation was to determine the incidence of sperm-bound antibodies in the male partners of an unselected infertile population using an immunologically specific test (IBT). With this method 34 out of 450 infertile men (7.55%) were positive for one or more of the immunoglobulins IgA, IgG and IgM. For IgG and IgA, the majority of antibody binding was located on the entire sperm with a minor amount bound to the head or tail. For the IgM, the majority of the binding was detected to the tail tip, and tail binding was observed only in a minority of cases.

摘要

本研究的目的是使用免疫特异性检测方法（免疫珠试验，IBT）来确定未经过挑选的不育人群男性伴侣中精子结合抗体的发生率。采用这种方法，450名不育男性中有34名（7.55%）一种或多种免疫球蛋白IgA、IgG和IgM呈阳性。对于IgG和IgA，大多数抗体结合位于整个精子上，只有少量结合在头部或尾部。对于IgM，大多数结合检测到位于尾尖，仅在少数情况下观察到尾部结合。