Bernardi Fabiana C, Vuolo Francieli, Petronilho Fabricia, Michels Monique, Ritter Cristiane, Dal-Pizzol Felipe
Universidade do Extremo Sul Catarinense, Criciúma, SC, Brasil.
Universidade do Sul de Santa Catarina, Tubarão, SC, Brasil.
An Acad Bras Cienc. 2015 Apr-Jun;87(2):713-9. doi: 10.1590/0001-3765201520140069. Epub 2015 May 15.
The aim of this study was to determine parameters of NO metabolism in plasma and placenta of preeclamptic (PE) patients. It was conducted a case-control study at São José Hospital, Brazil. Thirty-three PE and 33 normotensive pregnant were included in the study. The diagnosis of PE was established in accordance with the definitions of American College of Obstetricians and Gynecologists. Peripheral venous blood and placenta samples were obtained at postpartum period. Plasma NO levels and SOD activity were significantly lower and endothelin-1 levels and arginase activity were significantly higher in PE women when compared to controls. None of the analyzed parameters were different in the placenta between groups. Our findings suggest that parameters associated with NO metabolism are altered only at the systemic level, but not in placenta of PE patients.
本研究的目的是确定子痫前期（PE）患者血浆和胎盘中一氧化氮（NO）代谢的参数。该研究在巴西圣若泽医院进行了一项病例对照研究。33例PE患者和33例血压正常的孕妇被纳入研究。PE的诊断依据美国妇产科医师学会的定义确定。在产后采集外周静脉血和胎盘样本。与对照组相比，PE女性的血浆NO水平和超氧化物歧化酶（SOD）活性显著降低，内皮素-1水平和精氨酸酶活性显著升高。两组胎盘之间的所有分析参数均无差异。我们的研究结果表明，与NO代谢相关的参数仅在全身水平发生改变，而在PE患者的胎盘中未发生改变。
