Thyroid disorders are common in first-degree relatives of individuals with type 1 diabetes mellitus.
作者信息
Araujo Débora Batista, Barone Bianca, Melleti Natasha Ferreira Teixeira, Dantas Joana Rodrigues, Oliveira Marcus Miranda dos Santos, Zajdenverg Lenita, Tortora Rosangela Prendim, Vaisman Mario, Milech Adolpho, Oliveira José Egídio Paulo de, Rodacki Melanie
机构信息
Department of Internal Medicine, Diabetes and Nutritional Diseases Section, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
State Institute of Diabetes and Endocrinology Luiz Capriglione, Rio de Janeiro, RJ, Brazil.
出版信息
Arch Endocrinol Metab. 2015 Apr;59(2):112-5. doi: 10.1590/2359-3997000000022. Epub 2015 Apr 1.
OBJECTIVE
Thyroid diseases are common in individuals with type 1 diabetes mellitus (T1DM) and should be investigated annually in these individuals. The aim of this study was to evaluate the frequency of thyroid diseases in first degree relatives (FDR) of patients with T1DM.
SUBJECTS AND METHODS
Eighty individuals (40 patients with T1DM and 40 FDR) were interviewed and blood was sampled for thyroid-stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase (TPO) antibodies measurement. Autoantibodies against glutamic acid decarboxylase 65 (GAD65), islet antigen-2 (IA2) and autoantibodies against insulin (AAI) were measured in FDR.
RESULTS
We found a similar prevalence of thyroid dysfunction in patients with T1DM and their FDR (22.5% vs. 27.5%; p = 0,79). There were no differences in serum TSH levels (p = 0.29), FT4 (p = 0,45), frequency of abnormal TSH (p = 0.28), positive TPO antibodies (p = 0.13), titers of TPO antibodies (in positive cases) between patients with T1DM and their FDR (p = 0.94).
CONCLUSIONS
Thyroid abnormalities seem to be common not only in patients with T1DM but also in their FDR, which suggests that screening strategies for thyroid diseases might also be useful to these individuals.
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