溶瘤病毒：从实验室到临床，重点关注安全性。
Oncolytic viruses: From bench to bedside with a focus on safety.
作者信息
Buijs Pascal R A, Verhagen Judith H E, van Eijck Casper H J, van den Hoogen Bernadette G
机构信息
a Department of Surgery; Erasmus MC; University Medical Center ; Rotterdam , The Netherlands.
出版信息
Hum Vaccin Immunother. 2015;11(7):1573-84. doi: 10.1080/21645515.2015.1037058.
Abstract
Oncolytic viruses are a relatively new class of anti-cancer immunotherapy agents. Several viruses have undergone evaluation in clinical trials in the last decades, and the first agent is about to be approved to be used as a novel cancer therapy modality. In the current review, an overview is presented on recent (pre)clinical developments in the field of oncolytic viruses that have previously been or currently are being evaluated in clinical trials. Special attention is given to possible safety issues like toxicity, environmental shedding, mutation and reversion to wildtype virus.
摘要
溶瘤病毒是一类相对较新的抗癌免疫治疗药物。在过去几十年中，几种病毒已在临床试验中接受评估，并且第一种药物即将被批准用作一种新型癌症治疗方式。在当前的综述中，对溶瘤病毒领域最近的（临床前）临床进展进行了概述，这些溶瘤病毒此前已在临床试验中接受评估或目前正在接受评估。特别关注了可能的安全问题，如毒性、环境释放、突变以及回复为野生型病毒。
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