Jiang Wenyan, Gong Gaolang, Wu Feng, Kong Lingtao, Chen Kaiyuan, Cui Wenhui, Ren Ling, Fan Guoguang, Sun Wenge, Ma Huan, Xu Ke, Tang Yanqing, Wang Fei
Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China; Department of Radiology, The Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, PR China.
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, PR China.
PLoS One. 2015 May 21;10(5):e0126673. doi: 10.1371/journal.pone.0126673. eCollection 2015.
Previous findings suggest that the Papez Circuit may have a role in major depressive disorders. We used atlas-based tract-specific quantification analysis and voxel-based analysis to examine the integrity of white matter tracts involved in mood regulation (including tracts in the Papez Circuit). Diffusion tensor imaging acquired from 35 first-episode, treatment-naive adults with major depressive disorders and 34 healthy adult controls were compared. Our statistical approach compared structural integrity of 11 major white matter tracts between the major depressive disorder and adult controls, as well as illness duration influence in patients. Fractional anisotropy was decreased in the hippocampal cingulum and in the anterior thalamic radiation according to both analytical approaches, all of which were important tracts included in the Papez Circuit. Our results support the role of the Papez Circuit in major depressive disorders with the minimal probability of false positive due to similar findings in both analyses that have complementary advantages. Dysfunction of the Papez Circuit may be a potential marker for studying the pathogenesis of major depressive disorders.
先前的研究结果表明，帕佩兹环路可能在重度抑郁症中起作用。我们使用基于图谱的特定束定量分析和基于体素的分析来检查参与情绪调节的白质束（包括帕佩兹环路中的束）的完整性。比较了从35名首次发作、未接受过治疗的重度抑郁症成年患者和34名健康成年对照者获得的扩散张量成像。我们的统计方法比较了重度抑郁症患者和成年对照者之间11条主要白质束的结构完整性，以及患者的病程影响。根据两种分析方法，海马扣带和丘脑前辐射中的分数各向异性均降低，所有这些都是帕佩兹环路中重要的束。我们的结果支持帕佩兹环路在重度抑郁症中的作用，由于两种分析具有互补优势且结果相似，因此假阳性的可能性最小。帕佩兹环路功能障碍可能是研究重度抑郁症发病机制的潜在标志物。
