Curtis J R, Sampson B
Department of Medicine, Charing Cross Hospital, Fulham, London, U.K.
Int J Artif Organs. 1989 Nov;12(11):683-7.
Aluminium kinetics of the Redy 2000 Sorbsystem using D3260 cartridges and the latest pre-treatment protocol have been studied in vitro and in vivo. In 7 patients, aluminium kinetics were studied during haemodialysis using the Redy 2000 Sorbysystem, D3260 cartridges. S557 acetate concentrate and Gambro hollow fibre dialyser (cuprophane 120M). The same patients were also studied during conventional haemodialysis using the Gambro AK10 proportionating system with acetate dialysate and Gambro hollow fibre dialyser (cuprophane 120M). There was no significant rise in plasma aluminium concentration during dialysis on the Redy 2000 Sorbsystem. The post-dialysis plasma aluminium concentrations were significantly higher after conventional haemodialysis, however, and the explanation for this is not clear but is not accounted for by differences in the degree of ultrafiltration during the studies. A significant rise in dialysate aluminium concentration was observed after 4 hours of dialysis on the Redy 2000 Sorbsystem. The manufacturer's ammonia test papers appear to be too insensitive as indicators of cartridge exhaustion and dialysate pH may be better. The D3260 cartridges should be used for a maximum of 4 hours only. Further long-term studies of aluminium kinetics using this system are justified.
使用D3260滤芯和最新预处理方案的Redy 2000吸附系统的铝动力学已在体外和体内进行了研究。在7名患者中，使用Redy 2000吸附系统、D3260滤芯、S557醋酸盐浓缩液和金宝中空纤维透析器（铜仿膜120M）进行血液透析期间研究了铝动力学。同样的患者在使用金宝AK10比例系统和醋酸盐透析液以及金宝中空纤维透析器（铜仿膜120M）进行常规血液透析期间也进行了研究。在Redy 2000吸附系统上进行透析期间，血浆铝浓度没有显著升高。然而，常规血液透析后透析后血浆铝浓度显著更高，对此的解释尚不清楚，但不是由研究期间超滤程度的差异导致的。在Redy 2000吸附系统上透析4小时后，观察到透析液铝浓度显著升高。制造商的氨试纸作为滤芯耗尽的指标似乎过于不敏感，透析液pH值可能更好。D3260滤芯最多只能使用4小时。使用该系统对铝动力学进行进一步的长期研究是合理的。
