Odette Cancer Centre, Toronto, Ontario, Canada; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto.
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Lung Cancer. 2015 Jul;89(1):4-7. doi: 10.1016/j.lungcan.2015.04.006. Epub 2015 Apr 25.
Although prophylactic cranial irradiation (PCI) has been the standard of practice for patients successfully treated for limited stage small cell lung cancer for decades, subsequent changes in patient selection, updated brain imaging guidelines, an increased understanding of the mechanisms underlying the deleterious effects of whole brain irradiation as well as ongoing investigations into improving radiation treatment delivery have begun to question the current role of PCI. Who should be treated and how? This review attempts to gather together evidence for improving patient selection and describe potential improvements in treatment delivery.
虽然预防性颅照射（PCI）几十年来一直是治疗局限期小细胞肺癌成功患者的标准治疗方法，但随着患者选择的改变、更新的脑部成像指南、对全脑放疗有害影响机制的深入了解以及对改善放疗实施的持续研究，开始对 PCI 的当前作用提出质疑。谁应该接受治疗以及如何治疗？本综述试图收集改善患者选择的证据，并描述治疗实施的潜在改进。
