Orrenius Sten, Gogvadze Vladimir, Zhivotovsky Boris
Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, SE-171 77 Stockholm, Sweden; MV Lomonosov Moscow State University, 119991 Moscow, Russia.
Biochem Biophys Res Commun. 2015 Apr 24;460(1):72-81. doi: 10.1016/j.bbrc.2015.01.137.
The calcium ion has long been known to play an important role in cell death regulation. Hence, necrotic cell death was early associated with intracellular Ca(2+) overload, leading to mitochondrial permeability transition and functional collapse. Subsequent characterization of the signaling pathways in apoptosis revealed that Ca(2+)/calpain was critically involved in the processing of the mitochondrially localized, Apoptosis Inducing Factor. More recently, the calcium ion has been demonstrated to play important regulatory roles also in other cell death modalities, notably autophagic cell death and anoikis. In this review, we summarize current knowledge about the mechanisms involved in Ca(2+) regulation of these various modes of cell death with a focus on the importance of the mitochondria.
长期以来，人们一直认为钙离子在细胞死亡调控中发挥着重要作用。因此，坏死性细胞死亡早期与细胞内钙离子过载相关，导致线粒体通透性转变和功能崩溃。随后对凋亡信号通路的表征揭示，钙离子/钙蛋白酶在位于线粒体的凋亡诱导因子的加工过程中起关键作用。最近，钙离子也被证明在其他细胞死亡方式中发挥重要调节作用，尤其是自噬性细胞死亡和失巢凋亡。在本综述中，我们总结了目前关于钙离子调控这些不同细胞死亡模式所涉及机制的知识，重点关注线粒体的重要性。
