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A Commentary On: "NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer's Disease". A cautionary note regarding C3aR.关于《NFκB激活的星形胶质细胞释放补体C3损害与阿尔茨海默病相关的神经元形态和功能》的评论。关于C3aR的警示说明。
Front Immunol. 2015 May 7;6:220. doi: 10.3389/fimmu.2015.00220. eCollection 2015.
2
NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease.核因子κB激活的星形胶质细胞释放补体C3会损害与阿尔茨海默病相关的神经元形态和功能。
Neuron. 2015 Jan 7;85(1):101-115. doi: 10.1016/j.neuron.2014.11.018. Epub 2014 Dec 18.
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Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease.丁酰胆碱酯酶活性的功能变异性调节阿尔茨海默病患者鞘内细胞因子和神经胶质生物标志物谱。
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Expression of anaphylatoxin receptors on platelets in patients with coronary heart disease.冠心病患者血小板上过敏毒素受体的表达
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Alzheimer's disease plaques and tangles: cemeteries of a pyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction.阿尔茨海默病斑块和缠结：免疫防御网络对抗单纯疱疹感染的得不偿失的胜利之墓，代价是补体和炎症介导的神经元破坏。
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Osteoclast-derived complement component 3a stimulates osteoblast differentiation.破骨细胞衍生的补体成分 3a 刺激成骨细胞分化。
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Cytokines associated with amyloid plaques in Alzheimer's disease brain stimulate human glial and neuronal cell cultures to secrete early complement proteins, but not C1-inhibitor.与阿尔茨海默病大脑中淀粉样斑块相关的细胞因子刺激人类神经胶质细胞和神经元细胞培养物分泌早期补体蛋白，但不分泌C1抑制剂。
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The many effects of complement C3- and C5-binding proteins in renal injury.补体C3和C5结合蛋白在肾损伤中的多种作用。
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The Complement C3a and C3a Receptor Pathway in Kidney Diseases.补体 C3a 和 C3a 受体通路在肾脏疾病中的作用。
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VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice.VGF 衍生肽 TLQP-21 通过 C3aR1 信号通路调节小胶质细胞功能，并减少 5xFAD 小鼠的神经病理学改变。
Mol Neurodegener. 2020 Jan 10;15(1):4. doi: 10.1186/s13024-020-0357-x.
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Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury.骨髓间充质干细胞来源的外泌体抑制脊髓损伤大鼠的补体激活
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Inhibition of the alternative complement pathway accelerates repair processes in the murine model of choroidal neovascularization.抑制替代补体途径可加速实验性脉络膜新生血管模型的修复过程。
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NF-κB signaling pathway-enhanced complement activation mediates renal injury in trichloroethylene-sensitized mice.NF-κB 信号通路增强的补体激活介导三氯乙烯致敏小鼠的肾损伤。
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本文引用的文献

1
Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth.补体激活产物C3a是一种促炎分子吗？重新评估证据与误解。
J Immunol. 2015 Apr 15;194(8):3542-8. doi: 10.4049/jimmunol.1403068.
2
Neurodegenerative disease: Factoring in astrocytes.神经退行性疾病：考虑星形胶质细胞的因素。
Nat Rev Neurosci. 2015 Feb;16(2):67. doi: 10.1038/nrn3908.
3
NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease.核因子κB激活的星形胶质细胞释放补体C3会损害与阿尔茨海默病相关的神经元形态和功能。
Neuron. 2015 Jan 7;85(1):101-115. doi: 10.1016/j.neuron.2014.11.018. Epub 2014 Dec 18.
4
The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization.补体成分 C3a 的受体通过抑制中性粒细胞动员来介导对肠道缺血再灌注损伤的保护作用。
Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9439-44. doi: 10.1073/pnas.1218815110. Epub 2013 May 21.
5
Role of the complement components C5 and C3a in a mouse model of myocardial ischemia and reperfusion injury.补体成分C5和C3a在心肌缺血再灌注损伤小鼠模型中的作用。
Ger Med Sci. 2010 Sep 8;8:Doc20. doi: 10.3205/000109.
6
The C3a receptor antagonist SB 290157 has agonist activity.C3a受体拮抗剂SB 290157具有激动剂活性。
Immunol Lett. 2005 Sep 15;100(2):139-45. doi: 10.1016/j.imlet.2005.03.003. Epub 2005 Mar 25.
7
Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury.在大鼠肠缺血/再灌注损伤模型中C3a和C5a受体拮抗剂的抗炎活性比较
Br J Pharmacol. 2004 Jun;142(4):756-64. doi: 10.1038/sj.bjp.0705819. Epub 2004 May 24.
8
Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models.一种选择性非肽类过敏毒素C3a受体拮抗剂的鉴定，该拮抗剂在动物模型中表现出抗炎活性。
J Immunol. 2001 May 15;166(10):6341-8. doi: 10.4049/jimmunol.166.10.6341.

A Commentary On: "NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer's Disease". A cautionary note regarding C3aR.

作者信息

Woodruff Trent M, Tenner Andrea J

机构信息

School of Biomedical Sciences, The University of Queensland , Brisbane, QLD , Australia.

Department of Molecular Biology and Biochemistry, Institute for Memory Impairment and Neurological Disorders, University of California-Irvine , Irvine, CA , USA.

出版信息

Front Immunol. 2015 May 7;6:220. doi: 10.3389/fimmu.2015.00220. eCollection 2015.

DOI:10.3389/fimmu.2015.00220
PMID:25999955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4423305/
Abstract
摘要