以肽为模板的金纳米簇的绿色合成作为检测蛋白激酶活性的新型荧光探针。
Green synthesis of peptide-templated gold nanoclusters as novel fluorescence probes for detecting protein kinase activity.
作者信息
Song Wei, Liang Ru-Ping, Wang Ying, Zhang Li, Qiu Jian-Ding
机构信息
Department of Chemistry, Nanchang University, Nanchang 330031, China.
出版信息
Chem Commun (Camb). 2015 Jun 21;51(49):10006-9. doi: 10.1039/c5cc02280k.
PMID:26001023
Abstract
A green method was employed for synthesizing peptide-templated nanoclusters without requiring strong reducing agents. Using synthetic peptide-gold nanoclusters as fluorescence probes, a novel assay for detecting protein kinase is developed based on phosphorylation against carboxypeptidase Y digestion.
摘要
采用一种绿色方法合成肽模板纳米簇，无需强还原剂。以合成的肽-金纳米簇作为荧光探针，基于针对羧肽酶Y消化的磷酸化作用，开发了一种检测蛋白激酶的新方法。
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