Hwang In Kyeom, Kang Bong Kyun, Lee Yoon Suk, Cho Jai Young, Yoon Yoo-Seok, Hwang Jin-Hyeok, Han Ho-Seong, Kim Jaihwan
Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Korea.
Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Korea.
Am J Surg. 2015 Nov;210(5):871-7. doi: 10.1016/j.amjsurg.2014.12.051. Epub 2015 Apr 30.
Information regarding postoperative thromboembolism in curatively resected pancreatic cancer is limited. This study aimed to assess the incidence and significance of postoperative thromboembolism.
We retrospectively reviewed the medical records of 121 curatively resected pancreatic cancer patients. Early and late thromboembolisms were defined as events that occurred within 1 year and after 1 year, respectively.
Twenty-two patients (18%) experienced thromboembolism. Seven thromboembolic events occurred within 1 month (7, 6%), and the incidence rate decreased over time. Ten (63%) of the 16 patients with early thromboembolism experienced thromboembolism before or at the same time as recurrence; however, 5 (83%) of the 6 patients with late thromboembolism experienced recurrence before thromboembolism (P = .005). A significant difference in recurrence-free survival (P = .016) and borderline difference in overall survival (P = .050) were observed between patients with early thromboembolism and others.
Thromboembolic events after curative surgery are prevalent in pancreatic cancer, especially within 1 month. Thromboembolic events within 1 year of surgery should be cautiously monitored.
关于根治性切除的胰腺癌术后血栓栓塞的信息有限。本研究旨在评估术后血栓栓塞的发生率及意义。
我们回顾性分析了121例根治性切除的胰腺癌患者的病历。早期和晚期血栓栓塞分别定义为在1年内和1年后发生的事件。
22例患者（18%）发生血栓栓塞。7例血栓栓塞事件发生在1个月内（7例，6%），且发生率随时间下降。16例早期血栓栓塞患者中有10例（63%）在复发前或复发时发生血栓栓塞；然而，6例晚期血栓栓塞患者中有5例（83%）在血栓栓塞前复发（P = 0.005）。早期血栓栓塞患者与其他患者之间在无复发生存率方面存在显著差异（P = 0.016），在总生存率方面存在临界差异（P = 0.050）。
根治性手术后的血栓栓塞事件在胰腺癌中很常见，尤其是在1个月内。术后1年内的血栓栓塞事件应谨慎监测。
