Bryan Allen, Youngster Ilan, McAdam Alexander J
Division of Laboratory Medicine, Department of Pathology, Beth-Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.
Division of Infectious Diseases, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Clin Lab Med. 2015 Jun;35(2):247-72. doi: 10.1016/j.cll.2015.02.004. Epub 2015 Mar 18.
Shiga toxin-producing Escherichia coli (STEC) is among the common causes of foodborne gastroenteritis. STEC is defined by the production of specific toxins, but within this pathotype there is a diverse group of organisms. This diversity has important consequences for understanding the pathogenesis of the organism, as well as for selecting the optimum strategy for diagnostic testing in the clinical laboratory. This review includes discussions of the mechanisms of pathogenesis, the range of manifestations of infection, and the several different methods of laboratory detection of Shiga toxin-producing E coli.
产志贺毒素大肠杆菌（STEC）是食源性肠胃炎的常见病因之一。STEC通过特定毒素的产生来定义，但在这一病理类型中存在多种不同的生物体。这种多样性对于理解该生物体的发病机制以及在临床实验室中选择最佳诊断检测策略具有重要意义。本综述包括对发病机制、感染表现范围以及几种不同的产志贺毒素大肠杆菌实验室检测方法的讨论。
