用于HPPH介导的胸膜光动力疗法的光剂量测定
light dosimetry for HPPH-mediated pleural PDT.
作者信息
Dimofte Andreea, Zhu Timothy C, Finlay Jarod C, Cullighan Melissa, Edmonds Christine E, Friedberg Joseph S, Cengel Keith, Hahn Stephen M
机构信息
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA.
Department of Surgery, University of Pennsylvania, Philadelphia, PA.
出版信息
Proc SPIE Int Soc Opt Eng. 2010 Mar 4;7551. doi: 10.1117/12.851514.
This study examines the light fluence (rate) delivered to patients undergoing pleural PDT as a function of treatment time, treatment volume and surface area. The accuracy of treatment delivery is analyzed as a function of the calibration accuracies of each isotropic detector and the calibration integrating sphere. The patients studied here are enrolled in a Phase I clinical trial of HPPH-mediated PDT for the treatment of non-small cell lung cancer with pleural effusion. Patients are administered 4mg per kg body weight HPPH 24-48 hours before the surgery. Patients undergoing photodynamic therapy (PDT) are treated with light therapy with a fluence of 15-60 J/cm at 661nm. Fluence rate (mW/cm) and cumulative fluence (J/cm) is monitored at 7 different sites during the entire light treatment delivery. Isotropic detectors are used for in-vivo light dosimetry. The anisotropy of each isotropic detector was found to be within 15%. The mean fluence rate delivery and treatment time are recorded. A correlation between the treatment time and the treatment volume is established. The result can be used as a clinical guideline for future pleural PDT treatment.
本研究考察了接受胸膜光动力疗法（PDT）的患者所接受的光通量（率）与治疗时间、治疗体积和表面积之间的函数关系。分析了治疗剂量的准确性与每个各向同性探测器及校准积分球校准精度之间的函数关系。此处所研究的患者参加了一项采用HPPH介导的光动力疗法治疗伴有胸腔积液的非小细胞肺癌的I期临床试验。患者在手术前24 - 48小时按每公斤体重4毫克的剂量给予HPPH。接受光动力疗法（PDT）的患者采用661纳米波长、通量为15 - 60 J/cm²的光疗进行治疗。在整个光治疗过程中，在7个不同部位监测通量率（mW/cm²）和累积通量（J/cm²）。各向同性探测器用于体内光剂量测定。发现每个各向同性探测器的各向异性在15%以内。记录平均通量率和治疗时间。建立治疗时间与治疗体积之间的相关性。该结果可作为未来胸膜光动力疗法治疗的临床指南。
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