1 Deakin Child Study Centre, School of Psychology, Deakin University, Burwood, Victoria, Australia.
2 Murdoch Childrens Research Institute, Parkville, Victoria, Australia.
J Atten Disord. 2018 Aug;22(10):1002-1007. doi: 10.1177/1087054715587096. Epub 2015 May 25.
To examine (a) physical and daily functioning in children with ADHD and autism spectrum disorder (ASD) compared with ADHD alone and (b) whether decreased physical quality of life (QoL) is associated with increased emotional and behavioral problems in children with ADHD-ASD.
Cross-sectional study comprising 392 children with confirmed ADHD (ADHD-ASD, n = 93; ADHD alone, n = 299) recruited from 21 pediatric practices in Victoria, Australia. Data were collected via parent and teacher surveys. Key measures included the Strengths and Difficulties Questionnaire (SDQ) and Pediatric Quality of Life Inventory (PedsQL).
Children with ADHD-ASD had poorer QoL across both psychosocial and physical health domains, and also had greater parent-reported behavioral, emotional, and peer problems, compared with children with ADHD alone. Poorer physical QoL partially mediated the relationship between comorbid ASD status and poorer emotional and behavioral functioning.
The comorbid overlay of ASD in ADHD appears to influence not only problems in physical functioning but also the severity of problems relating to areas of emotional and behavioral functioning.
研究（a）患有注意缺陷多动障碍（ADHD）和自闭症谱系障碍（ASD）的儿童与仅患有 ADHD 的儿童相比在身体和日常功能方面的情况，以及（b）身体生活质量（QoL）下降是否与 ADHD-ASD 儿童的情绪和行为问题增加有关。
这是一项横断面研究，纳入了澳大利亚维多利亚州 21 家儿科诊所的 392 名确诊为 ADHD 的儿童（ADHD-ASD 组，n=93；仅 ADHD 组，n=299）。通过家长和教师调查收集数据。主要评估指标包括《长处与困难问卷》（SDQ）和《儿科生活质量量表》（PedsQL）。
与仅患有 ADHD 的儿童相比，ADHD-ASD 儿童在心理社会和身体健康领域的 QoL 均较差，且家长报告的行为、情绪和同伴问题也更多。较差的身体 QoL 部分中介了 ASD 共病状态与情绪和行为功能障碍严重程度之间的关系。
ADHD 中 ASD 的共病影响不仅是身体功能障碍的严重程度，还包括与情绪和行为功能相关的问题的严重程度。
